Mariana Genesio began her career as an actress at the renowned Dorian Gray nightclub in her hometown of Córdoba, Argentina (2004-2008). There she formed the company Cabaret together with a group of young local artists. During those years, she also worked with photographer Luizo Vega (Project Drakula - International Festival of Theater of Mercosur.)

In 2008 she settled in Buenos Aires to study theater and soon began to work as a fashion model for various designers; among them the renowned designer Roberto Piazza. Mariana continued training and acting with Sebastián Pajoni, working as well as a fashion model and radio reporter on Urban Offerings and FM The tribe. In 2012 she played Angustias in the cast of La Casa de Bernarda Alba by Federico García Lorca.  In 2013 Mariana produced and starred with Alejandro Colleti in The Apocalypse according to M written by her husband and collaborator Nicolás Giacobone and directed by Juan F. Carol. In this play, her character spends most of the time solo on stage, relaying her theories and existential doubts straight to the audience, while acting out various women stereotypes.

While accompanying her husband in various award ceremonies including The Golden Globes, Baftas, Oscars, Mariana had the opportunity to wear some incredible high end fashion. This peaked her interest in collaborating and working with several haute couture designers, like Ana Pugliesi who called her to model in a campaign shot in the streets of Manhattan. Mariana also worked in fashion campaigns for Sylvio NYC and in 2016 she was summoned by the artist Luizo Vega to perform productions in Paris: Dracula Is Not Dead, Springsioux and Herve LeRoux.

Mariana is continuing her training in renowned acting schools, like the Stella Adler Studio, T. Schreiber Studio and the Michael Howard Studio. In 2016 she was chosen to be part of the cast of Street Children, the first work of author Pia Scala-Zankel. This was an Off Broadway production that garnered positive reviews including The New York Times, which led Street Children to be a completely sold out show.
In 2017 she participated in the Midtown International Theatre Festival with the play Difficult Transition, written by Kevin Clancy.
Currently Mariana is preparing her film debut with an adaptation made by Nicolás Giacobone of the play Folding The Monster, by Alexander Dinelaris.